A. Toyota, Y. Ono, C. Kaneko
Nov 18, 1996
Citations
0
Influential Citations
16
Citations
Journal
Tetrahedron Letters
Abstract
A novel method consisting four-step from tert-butyl acrylate (4) and chloromethyl phenyl sulfoxide (5) for preparing cis-2-fluorocyclopropane-1-carboxylic acid (cis-3) was elaborated. The method involves initial formation of the cis-2-phenylsulfinylcyclopropanecarboxylate (cis-6), fluorination by molecular fluorine to trans-7, reductive desulfonylation to the ester (cis-9) and acid-catalyzed hydrolysis to the final product (cis-3).