Benjamin Loosley, R. Andersen, G. Dake
Feb 15, 2013
Citations
0
Influential Citations
22
Citations
Journal
Organic letters
Abstract
The total synthesis of cladoniamide G, a cytotoxic compound against MCF-7 breast cancer cells (10 μg/mL), was accomplished. Key steps in the sequence include oxidative dimerization of 3-acetoxy-5-chloroindole and a tandem process incorporating three steps: bimolecular carbonyl addition, lactam formation, and carbamate removal.