N. Foroughifar, A. Mobinikhaledi, S. Ebrahimi
Feb 18, 2009
Citations
0
Influential Citations
39
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A series of new 1,2/1,3-bis[ o -( N -methylidenamino-5-aryl-3-thiol-4 H -1,2,4-triazole-4-yl)phenoxy]alkane derivatives 3a – d and bis[ o -( N -methylidenamino-2-thiol-1,3,4-thiadiazole-5-yl)phenoxy]alkanes 6a – c were prepared by condensation of 4-amino-5-(aroyl)-4 H -1,2,4-triazole-3-thiols 2a – b or 2-amino-5-mercapto-1,3,4-thiadiazole with bis-aldehydes 1a – c . Further reaction of compounds 3a – d and 6a – c with dibromoalkanes afforded the new macrocycles 5a – f and 8a – d . The cyclization does not require high dilution techniques and provides the expected azathia macrocycles in good yields, ranging from 55% to 68%.