U. Ramulu, D. Ramesh, S. Rajaram
Jan 31, 2012
Citations
1
Influential Citations
24
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract A simple and efficient stereoselective synthesis of clonostachydiol was achieved using ethyl ( R )-3-hydroxybutanoate 5 and methyl ( R )-2-hydroxypropanoate 12 as readily available starting materials. The key steps involved in the synthesis were MacMillan α-hydroxylation, Horner–Wadsworth–Emmons (HWE) olefination, a Grignard reaction, and Hoveyda–Grubbs IInd generation catalyzed ring closing metathesis (RCM).