W. Shi, Shuainan Liu, Chengjin Wang
Nov 23, 2018
Citations
0
Influential Citations
13
Citations
Journal
The Journal of organic chemistry
Abstract
A tandem 1,1-dimethyltrifluoroethylation and cyclization of isonitriles with 3,3,3-trifluoro-2,2-dimethylpropanoic acid was developed. This protocol provides the efficient synthesis of a series of previously unknown CMe2CF3-containing heteroarenes, which are potentially useful in the drug discovery process.