Margaret A. Carter, B. Robinson
Jul 1, 1972
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Journal
Journal of Pharmacy and Pharmacology
Abstract
Recently a series of 3-amino-l,l-dimethyltetralins (Martin, Parulkar & others, 1969) and three compounds having structures (I, R=H, Me and CH,-CH=CMe,) (Harper & Raines, 1969) have been synthesized as potential analgesic agents. Although analgesic evaluation of the latter three compounds was not reported [subsequent to the completion of this present work, it has been brought to our attention by Dr. D. C. Bishop that these compounds do not possess analgesic activity], 1,1-dimethyl-3-dimethylaminotetralin (11, R = H, R' = NMe,) possessed an analgesic activity 2.5 times that of codeine (Martin & others, 1969). In view of this, and since compounds of type I possess a 2-aminotetralin moiety with a quarternary carbon atom at position 1, we have synthesized and pharmacologically evaluated the title compounds.