D. Sullins, T. Bobik, R. Wolfe
Jul 1, 1993
Citations
0
Influential Citations
6
Citations
Journal
Journal of the American Chemical Society
Abstract
Methanofuran, 3-{p-[(N-(N''((4R,5S)- or (4S,5R)-4,5,7-tricarboxyheptanoyl)-γ-L-glutamyl-γ-L-glutamyl)-β-amino)ethyl]phenoxymethyl}-5-(aminomethyl)furan, and methanofuran b, 3-{p-[N-(γ-L-glutamyl-γ-L-glutamyl-γ-L-glutamyl)-β-amino)ethyl]phenoxymethyl}-5-(aminomethyl)furan, are the first cofactors involved in the convertion of carbon dioxide to methane by the methanogenic bacteria Methanobacterium thermoautotriphicum and Methanosarcina barkeri, respectively. There two cofactors have now been synthesized, starting from glutamic acid, dimethyl glutarate, methyl 5-formyl-3-furoate, and tyramine. The synthetic compounds give the name NMR and mans spectra and biological activities an the natural cofactors