L. Ku
2015
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Journal
Fine Chemical Intermediates
Abstract
The impurity(ceftazidime methyl) produced in the synthesis of ceftazidime were analyzed and speculated,and 2- Mercaptobenzothiazolyl-( Z)-( 2- aminothiazol- 4- yl)- 2-( tert- butoxycarbonyl) isopropoxyiminoacetate(TAEM), a raw material for the synthesis of ceftazidime, was analyzed. The analytical results indicated that an unknown impurity existed in TAEM, and the experimental results from LC-MS and HPLC determination indicated that the existence of the impurity was related to a reaction between TAEM and methanol solvent. Based on the above deduction, a compound with the same molecular weight from LC-MS analysis and same retention time in HPLC analysis of the unknown impurity in TAEM was synthesized.