A. But, P. Lameiras, I. Silaghi-Dumitrescu
May 31, 2010
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0
Influential Citations
2
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Journal
ChemInform
Abstract
Starting from TRIS [2-amino-2-(hydroxymethyl) propane-1,3-diol] via its thia analogue, 2-amino-2-(mercaptomethyl) propane-1,3-diol' double cyclocondensation with formaldehyde, we report a four steps synthesis of the first term in the title series of compounds, bearing the exploitable hydroxymethyl functionality at the C-5 position. Conformational analysis is discussed based on DFT calculations and (1)H-DNMR.