Roberto Ciaschi, M. D'alagni
Dec 12, 1979
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Influential Citations
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Journal
Macromolecular Chemistry and Physics
Abstract
Poly(e-N-benzyloxycarbonyl-L-lysyl-L-valyl-e-N-benzyloxycarbonyl-L-lysine) (6) was synthesized via the p-nitrophenyl active ester method. The dipeptide and the active ester of the tripeptide were obtained by using tert-butoxycarbonyl-N-e-benzyloxycarbonyl-L-lysine succinimido ester and dicyclohexylcarbodiimide as condensing agents, respectively. Polymer 6 was investigated in the solid state by IR and X-ray diffraction measurements and in trifluoroethanol solution by UV, CD, and IR spectroscopy. The results obtained in the solid state indicate the occurrence of the β-conformation and some other unidentified conformation. No useful information was obtained from the study of the trifluoroethanol solution of 6. Once more it was found that the introduction of valyl residues in a chain, containing residues which are α-helix formers, seems to favour the β-structure.