E. Gálvez, M. Arias, B. Rico
Jul 1, 1989
Citations
0
Influential Citations
3
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A series of 10α-acyloxy-N-phenethyl-8-azabicyclo[4.3.1]decane derivatives have been synthesized and studied by 1H and 13C nmr spectroscopy, and the crystal structure of N-phenethyl-10aL-(xanten-9″-carbonyloxy)bicyclo[4.3.1]decane 2 has been determined by X-ray diffraction. The compounds studied display in deuteriochloroform the same preferred conformation adopted by the piperidine ring as a distorted chair conformation flattened at N-8 with both the phenethyl and acyloxy groups in the equatorial position with respect to the piperidine ring. These results are in close agreement with that found for compound 2 in the crystalline state.