V. Kubyshkin, Pavel K. Mykhailiuk, A. Ulrich
Oct 1, 2009
Citations
0
Influential Citations
3
Citations
Journal
Synthesis
Abstract
A new, conformationally rigid analogue of 2-amino- adipic acid, 8-((benzyloxy)carbonyl)-3-methylene-8-azabicyc- lo(3.2.1)octane-1,5-dicarboxylic acid, is synthesized from dimethyl rac-2,5-dibromohexanedioate. The key steps involve alkylation- cyclization of 1-benzyl 2,5-dimethyl pyrrolidine-1,2,5-tricarboxy- late with 3-chloro-2-(chloromethyl)prop-1-ene to yield the 8-azabi- cyclo(3.2.1)octane skeleton.