L. Dias, L. G. de Oliveira, Janaína D. Vilcachagua
Mar 1, 2005
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0
Influential Citations
48
Citations
Journal
The Journal of organic chemistry
Abstract
[structure: see text] The total synthesis of (+)-crocacin D is described. The convergent asymmetric synthesis relies on the use of a Stille cross-coupling between an (E)-vinyl stannane with an (E)-vinyl iodide to establish the (E,E)-dienamide moiety followed by a mild and efficient copper-catalyzed coupling between (+)-crocacin C and a (Z)-vinyl iodide to establish the challenging (Z)-enamide function.