N. Raj
May 15, 2020
Citations
0
Influential Citations
8
Citations
Journal
Journal of Molecular Structure
Abstract
Abstract N-(4-hydroxy-3-(morpholino(phenyl)methyl)phenyl) acetamide and N-(4-hydroxy-3-(piperidin-1-yl(phenyl)methyl)phenyl) acetamide derivatives have been synthesized via three component reaction of paracetamol, morpholine/piperidine and benzaldehyde. The reaction afforded these novel paracetamol derivatives in moderate to good yield. The solid state structures of some compounds were examined by X-rays from single crystals.The DNA-binding interactions of the compounds with calf thymus DNA have been studied by UV, visible, emission studies. The results were observed hypochromism with red shift suggesting that compounds interact with CT DNA via intercalation. The protein-binding interactions of the compounds with BSA were examined by fluorescence, synchronous fluorescence and UV, visible spectroscopic methods. All the compounds have the ability to bind strongly with BSA and a static quenching mechanism was observed.