C. A. Obafemi, P. Adelani, O. A. Fadare
Oct 8, 2013
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Quality indicators
Journal
Journal of Molecular Structure
Abstract
Abstract This work reports the synthesis and characterization of 2,3a,8b-trihydroxy-3-(thiophen-2-ylcarbonyl)-2-(trifluoromethyl)-2,3,3a,8b-tetrahydro-4H-indeno[1,2-b]furan-4-one. The compound was characterized by elemental analysis, IR, NMR and HREIMS spectra. The solid state structure of the title compound was established by single crystal X-ray diffraction. The crystal structure adopts triclinic space group P-1 , and stabilized by intermolecular non-covalent interactions. The intermolecular hydrogen bonding interactions, C H⋯F C and O H⋯O C, connect the molecules into a layered network structure. The compound showed broad spectrum (in vitro) activity against nine strains of Gram positive and four strains of Gram negative bacteria.