Xu Qiu-yan
2013
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Journal
Journal of University of South China
Abstract
Enantiopure compound(2R,3R,5S)-3,5-dimethy-2-(3-fluorinephenyl)-2-morpholinol hydro-chloride(4A)and(2S,3S,5R)-3,5-dimethy-2-(3-fluorinephenyl)-2-morpholinol hydrochloride(4B) was synthesized from(S)-2-amino-1-propanol and 2-bromo-m-fluorinephenone,(R)-2-amino-1-propanol and 2-bromo-m-fluorine-phenone.Single-crystal X-ray analysis was used to measure crystal structure and space structure.The compound 4A crystal belongs to orthorhombic system with space group P21212 and cell parameters:a=8.6886(12) nm,b=20.059(3) nm,c=7.6052(9) nm,Z=4,V=1.3255(6) nm3,Dc=1.311 g/cm3,F(000)=552,R1=0.0257,wR2=0.0650,S=1.021.The compound 4B crystal belongs to orthorhombic system with space group P21212 and cell parameters:a=8.6887(9) nm,b=20.064(2) nm,c=7.6135(7) nm,Z=4,V=1.3272(3) nm3,Dc=1.310 g/cm3,F(000)=552,R1=0.0356,wR2=0.0653,S=1.033.