Pengfei Zhou, A. Hou, Yang Wang
2018
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0
Influential Citations
3
Citations
Journal
Chinese Journal of Organic Chemistry
Abstract
The efficient total synthesis of cudratricusxanthone B ( 1 ), a biologically interesting natural isoprenylated xanthone, has been achieved for the first time starting from commercially available 2,4-dihydroxybenzoic acid via a linear reaction se-quence of 8 steps with the overall yield of 3.1%, wherein Claisen rearrangement and demethylation with AlCl 3 /pyridine are used as key reactions. This work definitely laid the foundation for the further pharmacological study of this natural compound. Meanwhile, another xanthone ( 2 ) has been synthesized, which proved the reported structure of the natural xanthone staudtiixanthone D to be wrong.