R. Dua, R. Phillips
1992
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The 5-bromo derivative 2 of the cyclic tautomer of N b -methoxycarbonyl-L-tryptophan methyl ester 1 undergoes reaction with CuCN in refluxing N-methylpyrrolidone (NMP) to give 5-cyano derivative 3a with some ring opened 5-cyano product 3b . Both 3a and 3b can be converted, in high yield, into free 5-cyano-L-tryptophan 4 with BBr 3 under mild conditions.