R. Nandhikumar, K. Subramani
2018
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0
Influential Citations
2
Citations
Journal
Asian Journal of Chemistry
Abstract
green synthesis of 1,8-naphthyridines like 2,2,2-trifluoro-1-(2-methyl-1,8-naphthyridin-3-yl)ethanone, 2,2,2-trifluoro-1-(2-phenyl-1,8-naphthyridin-3-yl)ethanone, 2-trifluoro-1-(2-phenyl-1,8-naphthyridin-3-yl)ethanone, 1-(2-(4-chlorophenyl)-1,8-naphthyridine-3-yl)-2,2,2-trifluoroethanone, 2,2,2-trifluoro-1-(2-(furan-2-yl)-1,8-naphthyridin-3-yl)ethanone and 2,2,2-trifluoro-1-(2-(thiophen-2-yl)-1,8-naphthyridin-3-yl)ethanone from ecofriendly and inexpensive NaH catalyzed Friedlander condensation of 2-aminonicotinaldehyde ( 1 ) through carbonyl complexes containing α -methylene moiety ( 2 ) has been achieved in eco-friendly by microwave irradiation. Elemental analysis, TLC, IR, 1 H NMR, 13 C NMR and GC-Mass spectroscopy were analyzed the compounds character. The final compounds were tested antimicrobial culture study. In the antibacterial and antifungal study the compounds 3d and 3e shows very good activity against Escherichia coli , Pseudomonas aeruginosa and Staphylococcus aureus and 3b , 3c , 3d , 3e and 3f shows good action against Penicillium species, Candida albicans and Aspergillus niger , compare to 3a . In this article, a very simple and low-cost method is described for the production of a novel sequence of 1,8-naphthyridines complex and provide very good microbial activity.