W. Gao, Zhigang Zhao, Yang Li
May 1, 2012
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Influential Citations
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Journal
Chinese Journal of Chemistry
Abstract
A facile synthesis of a series of new quinoline-8-carbaldehyde compounds, namely 8-formyl-2-(phenoxymethyl)quinoline-3-carboxylic acids (4a–4h) and 13-oxo-6,13-dihydro[1]benzoxepino[3,4-b]quinoline-8-carbaldehyde (5a–5g) is described, involving the one-pot synthesis reaction of ethyl 2-(chloromethyl)-8-formylquinoline-3-carboxylate (3) with substituted phenols followed by the intramolecular cyclization reaction via the treatment with polyphosphoric acid (PPA). Quinoline-8-carbaldehydes 4a–4h and 5a–5g are novel and their structures were supported by IR, 1H NMR, 13C NMR, MS and elemental analysis.