Xiangyang Wu, Jennifer L. Stockdill, Ping Wang
Mar 31, 2010
Citations
1
Influential Citations
79
Citations
Quality indicators
Journal
Journal of the American Chemical Society
Abstract
Recent developments in the use of isonitriles to furnish secondary and tertiary amide bond formations have been applied to a novel total synthesis of the important cyclic polypeptide cyclosporine A. Specifically, the disclosed synthetic route demonstrates the utility of microwave-mediated carboxylic acid isonitrile couplings, thioacid isonitrile couplings at ambient temperature, and isonitrile-mediated couplings of carboxylic acids and thioacids with amines to form challenging amide bonds.