Shen De-long
2009
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Triphenylphosphonium bromide(3)of acetyl cyclosporine A was obtained from cyclosporine A by acetylation,bromation and reacting with triphenylphosphine.Four new cyclosporine A derivatives were synthesized by the Wittig reaction of 3 with aldehydes and then deacetylation.The structures were confirmed by 1H NMR and MS.