Wen-Jian Song, Xiaodong Yang, Xianghui Zeng
May 15, 2012
Citations
0
Influential Citations
36
Citations
Quality indicators
Journal
RSC Advances
Abstract
A series of novel hybrid compounds between 2-substituted benzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results show that the hybrid compounds were more selective towards an ovarian carcinoma cell line (Skov-3) and suggest that hybrid compounds bearing 2-substituted benzofuran and benzimidazole moieties, as well as imidazolium salts, were vital for modulating cytotoxic activity. The 2-substituted benzofuran imidazole hybrids 24 and 8 can serve as valuable leads for further structural modifications.