R. Csuk, S. Schwarz, Bianka Siewert
Jul 1, 2012
Citations
0
Influential Citations
16
Citations
Journal
Zeitschrift für Naturforschung B
Abstract
Methyl glycyrrhetinate was esterified at position C3 of ring A using different amino acids. A short, unbranched chain of four carbon atoms with two amino groups in positions 2 and 4 was shown to be the most active compound of this series (IC50 = 0:8 M on liposarcoma Lipo cells). These compounds trigger apoptosis as shown by an acridine orange/ethidium bromide assay, trypan blue tests and DNA laddering experiments. Graphical Abstract Synthesis and Cytotoxic Activity of Methyl Glycyrrhetinate Esterified with Amino Acids