X. Bu, L. Deady, W. Denny
Jun 14, 2000
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0
Influential Citations
13
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Journal
Australian Journal of Chemistry
Abstract
The acid precursors of the title compounds were prepared from methyl 2-amino-3-formylbenzoate (3), by FriedlAnder synthesis with o-methoxy- and o-nitro-phenylacetic acids, phenylpyruvic acid and benzo[b]thiophen-2-one, respectively. Except for the last example, cyclization of an initial 3-arylquinoline derivative was then required to give the tetracycle. Growth inhibition properties of the carboxamides in a series of cancer cell lines were measured for comparison with previous data for an isomeric series. In all cases, the present set were found to be less active.