M. Noolvi, S. Agrawal, H. Patel
Apr 1, 2014
Citations
1
Influential Citations
40
Citations
Quality indicators
Journal
Arabian Journal of Chemistry
Abstract
A series of 1-methyl-N-((substituted-phenylmethylidene)-1H-benzimidazol-2-amines (4a-4g) were prepared via the formation of 1-methyl-1H-benzimidazol-2-amine (3), which was pre- pared by the cycloaddition of o-phenylenediamine (1) with cyanogen bromide in the presence of aqueous base followed by N-methylation with methyl iodide in the presence of anhydrous potas- sium carbonate in dry acetonitrile. Moreover, the four-membered b-lactam ring was introduced by the cycloaddition of 4a-4g and chloroacetyl chloride in the presence of triethylamine catalyst to give 3-chloro-1-(1-methyl-1H-benzimidazol-2-yl)-(4 0 -substituted)-phenylazetidin-2-one 5a-5g .A total of 14 compounds were synthesized and characterized by IR, 1 H NMR, 13 C NMR and Mass spectral technique, in addition they were evaluated for anti-bacterial and cytotoxic properties. Among the chemicals tested 4a, 4b, 5a, 5b, 5g exhibited good antibacterial activity and 5f, 5g shown good cytotoxic activity in vitro. a 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.