Journals Iosr, Priyanka B Kolanpaka, Sammaiah Gade
Apr 20, 2015
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Abstract
The present study involves synthesis of new heterocyclic moieties and screening them for cytotoxic and antioxidant activities. The titled compounds were synthesized by condensation reaction with different substituted isatin derivatives. The compounds were evaluated for their cytotoxic activity by MTT assay method and antioxidant activity by DPPH method. Among the compounds para chloro derivative was active as cytotoxic and ortho fluoro derivative was active as an antioxidant. II.2: Synthesis of N-{5-((4-fluorophenyl) carbonyl)-1H-benzimidazol-2-yl} -2-(3-oxo-2, 3-dihydro-1H- substitutedisoindol-1-yl) hydrazine carboxamides (III a-m): To a warm solution of N-{5-((4-fluorophenyl)carbonyl)-1H-benzimidazol-2-yl} hydrazine carboxamide (II) (0.01mol) in absolute ethanol (15ml) appropriate indole-2,3-dione (0.01mol) was added in the presence of glacial acetic acid (3 drops) and the reaction mixture was refluxed for 8-12 hr, then allowed to cool to room temperature. The solid separated was filtered, thoroughly washed with cold water, dried and recryastllized from ethanol. Compound III (a-m) were characterized by physical data, TLC, melting point, IR, Mass and PMR spectra. Melting points were determined in open capillary tubes on a Thomas Hoover melting point apparatus and were uncorrected.