N. Nam, D. Hong, Y. You
Jun 1, 2004
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Influential Citations
13
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Quality indicators
Journal
Archives of Pharmacal Research
Abstract
A series of 2, 5-dihydroxychalcones and related compounds were synthesized, and their cytotoxicities against tumor cell lines and human umbilical venous endothelial cells (HUVEC) evaluated. It was found that chalcones, with electron-withdrawing substituents on an A ring, exhibited significant cytotoxicities. Among the synthesized compounds, 2′-chloro-2, 5-dihydrox-ychalcone (9) was most potent, with an IC50 value as low as 0.31 μg/mL. This compound also exhibited a significant cytotoxic selectivity toward HUVEC.