N. Langlois, A. Rojas-Rousseau, C. Gaspard
Sep 29, 2001
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0
Influential Citations
31
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
A new 7,8-methylenedioxy analogue (4) of (+)-porothramycin B (2) and its water-soluble sodium bisulfite derivative (15) have been synthesized in high yields and have been shown to exhibit high cytotoxic activities against several tumor cell lines. The new pyrrolo[2,1-c][1,4]benzodiazepine 4 was as effective against the resistant cell lines as against the doxorubicin-sensitive cell lines tested.