Yongchun Hou, Xuejun Wu, W. Xie
Jan 29, 2001
Citations
0
Influential Citations
27
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1-S-nitroso-N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5- and 26-fold increased cytotoxicity was observed compared to glucose-2-SNAP and SNAP against DU-145 human prostate cancer cells in vitro.