F. S. Kimball, B. Turunen, Keith C Ellis
Apr 15, 2008
Citations
0
Influential Citations
11
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
An enantiospecific synthesis was developed to generate both enantiomers of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one. A biological assay utilizing the HCT-116 colon cancer cell line to determine the cytotoxicity of these analogs revealed that only the (R)-enantiomer exhibited appreciable cytotoxicity with an IC(50) value of 0.2 microM.