E. E. Gurdal, I. Durmaz, R. Cetin-Atalay
Mar 12, 2014
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Journal
Journal of Enzyme Inhibition and Medicinal Chemistry
Abstract
Abstract Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a–g) have higher growth inhibition than their carboxamide analogs.