You Zhou, Xiaoli Xu, Yuan Sun
May 15, 2013
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0
Influential Citations
24
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A novel series of amide derivatives of lomefloxacin were synthesized and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against a panel of five human cancer cell lines. Of the compounds prepared compounds 9d and 9g exhibited strong inhibition against topoisomerase II at 100μM. In addition, docking studies were performed to predict the inhibition mode.