Xiaohong Pan, Chunying Yang, J. Cleveland
Feb 10, 2016
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Influential Citations
14
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Journal
The Journal of organic chemistry
Abstract
Sempervirine and analogues were synthesized using a route featuring Sonogashira and Larock Pd-catalyzed reactions. Structure-activity relationships were investigated using three human cancer cell lines. 10-Fluorosempervirine is the most potently cytotoxic member of the family yet described.