Chen Na
2012
Citations
0
Influential Citations
0
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
Dabigatran etexilate was synthesized from 4-methylamino-3-nitrobenzoic acid(2) by acylchlorination and condensation with ethyl 3-(pyridin-2-ylamino)propanoate to give ethyl 3-[(4-methylamino-3-nitrobenzoyl)(pyridin-2-yl)amino]propanoate,which was subjected to reduction by hydrazine in the presence of Fe-Al-Cu complex catalyst,amidation,cyclization,amidination and acylation with an overall yield of about 33.6%(based on 2).