Wang Rong
2011
Citations
0
Influential Citations
1
Citations
Journal
Fine Chemical Intermediates
Abstract
Dasatinib was synthesized from methyl 2-amino-thiazole-5-carboxylate in an improved process via 2-chloro-6-methyl aniline as an intermediate in an overall yield of 41.5%,much higher than the usual value of 14.9%.This new process is more suitable for industrial production because of higher yield and lower cost.