Yuki Goto, K. Iwasaki, Kohei Torikai
Jun 5, 2009
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Influential Citations
48
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Journal
Chemical communications
Abstract
We report here the ribosomal synthesis of methyllanthionine-containing cyclic peptides involving a site-specific incorporation of vinylglycine under the reprogrammed genetic code, followed by the isomerization of the vinylglycine to dehydrobutyrine, and the subsequent intramolecular Michael addition of a cysteine residue placed at a downstream position of the vinylglycine.