R. Fernandes, Sandip V Mulay
Sep 17, 2010
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0
Influential Citations
34
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Journal
The Journal of organic chemistry
Abstract
The total synthesis of (+)-demethoxycardinalin 3 is described. The synthetic strategy features the synthesis of dimeric Fischer carbene and its use in a bidirectional Dötz benzannulation reaction to set the dimeric structure of the cardinalins. The oxa-Pictet-Spengler reaction was used to construct the pyran rings. The synthesis is completed in seven steps and an overall yield of 7%.