K. Chen
2015
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
Two intermediates,2,4,6-trimethoxybenzaldehyde( 2a) and 2,4,6-trideuteromethoxybenzaldehyde( 2b),were prepared from 2,4,6-trihydroxybenzaldehyde. Three deuterated Rigosertib analogs,in yield of 80% ~ 86%,were synthesized by the reaction of oxidization,condensation-decarboxylation,reduction,substitution and hydrolysis from [( 4-alkaxy-3-nitrobenyl)-thion]acetic acid. The structures were confirmed by1 H NMR and MS.