M. Ismail, D. Boykin
Mar 30, 2004
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0
Influential Citations
8
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
6-[5-(4-Amidinophenyl)furan-2-yl]nicotinamidine-d4 (5) was synthesized from 6-[5-(4-cyanophenyl)furan-2-yl]nicotinonitrile-d4 (3), through the bis-O-acetoxy-amidoxime followed by hydrogenation. Compound 3 was prepared from 6-(furan-2-yl)-nicotinonitrile by a Heck coupling reaction with 4-bromobenzonitrile-d4, a product of selective cyanation reaction of 1,4-dibromobenzene-d4 with Cu(1)CN. Deuterium-labelled N-methoxy-6-{5-[4-(N-methoxy-amidinophenyl]-furan-2-yl}-nicotinamidines were prepared via methylation of their respective amidoximes with dimethyl sulfate-d6 in aqueous sodium hydroxide in good yields. Copyright © 2004 John Wiley & Sons, Ltd.