Bang-Chi Chen, J. Sundeen, P. Guo
Mar 15, 2000
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Influential Citations
8
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde. Copyright © 2000 John Wiley & Sons, Ltd.