L. Tian, Li Xu, Jian Li
May 6, 2020
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Journal
Journal of Radioanalytical and Nuclear Chemistry
Abstract
The stable isotope-labeled rosuvastatin was requested in order to fully understand the metabolic process of rosuvastatin. An effective synthesis approach was developed for [2H4] rosuvastatin calcium. After ten steps, [2H4] rosuvastatin calcium was prepared with excellent chemical purification and isotope enrichment which can be applied as an internal standard. Moreover, this synthesis method could be useful in synthesis of other statins.