Y. Takemoto, Y. Baba, Asami Honda
Dec 17, 1998
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron
Abstract
Abstract The reaction of meso-(2, 4-hexadien-1, 6-dial)Fe(CO)3 complex1 with several alkylzincs in the presence of 50 mol% of(S)-(+)-diphenyl(1-methylpyrrolidin-2-yl)methanol6a proceeded with high enantiotopic group- and diastereotopic face-selectivity to give(2R, 6S)-alcohol complexes2a-c as major products, except in the case with dimethylzinc (>90% de and >98% ee). On the other hand, the methylation of1 with Me2Zn proceeded with high enantioselectivity by adding 1.8 equiv. ofTi(Oi-Pr)4 in the presence of 3 mol% of(S, S)-1, 2-bis(trifluoromethylsulfonamide)cyclohexane9a (82% de, 96% ee). The enantioselective alkylation was also applied to the kinetic resolution of racemic (sorbic aldehyde)Fe(CO)3 complex10. Download : Download full-size image