S. Morandi, Federica Pellati, S. Benvenuti
Jun 30, 2008
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron
Abstract
The first total synthesis of (8Z,13Z)-pentadeca-8,13-dien-11-yn-2-one is described. This dienynone was recently isolated from the n-hexane extract of Echinacea pallida roots and displayed a selective cytotoxic activity toward cancer cells, thus featuring as a potential anticancer lead. The product was obtained in 11 steps in 25% overall yield.