N. Matsumoto, Ryoji Hirose, S. Sasaki
Apr 1, 2008
Citations
0
Influential Citations
10
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
The key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate (13), for the immunomodulatory agent FTY720 (2: fingolimod) was synthesized via Michael addition of diethyl(acetylamino)malonate (6) to 4-octanoylstyrene (12).