Kaixia Sui, Yuting Leng, Yangjie Wu
Feb 14, 2023
Citations
0
Influential Citations
2
Citations
Journal
ACS Omega
Abstract
A highly efficient method for synthesis of difluoroarymethyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles with α,α-difluorophenylacetic acid as reaction substrates has been developed through radical cascade cyclization. The advantage of this strategy lies in excellent functional group tolerance to generate the corresponding products in good yields under base- and metal-free conditions.