Shilpa Barik, Sayan Shee, R. Gonnade
Nov 28, 2022
Citations
0
Influential Citations
4
Citations
Journal
Organic letters
Abstract
The N-heterocyclic carbene (NHC)-organocatalyzed [3 + 3] annulation of 2-bromoenals with β-oxodithioesters resulting in the enantioselective synthesis of dihydrothiopyranones is presented. The chiral α,β-unsaturated acylazoliums generated from 2-bromoenals and carbenes underwent smooth interception with the sulfur nucleophiles to furnish the sulfur heterocycles in satisfactory yields/selectivity. The regioselective formation of dihydrothiopyranones over the competing dihydropyranones is noteworthy.