S. Zhong, Angela E. E. Wandler, U. Schepers
Nov 1, 2015
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0
Influential Citations
7
Citations
Journal
European Journal of Organic Chemistry
Abstract
A variety of new symmetrical and unsymmetrical diketopiperazines have been prepared from free amino acids by using a previously developed microwave-assisted protocol. This included the successful incorporation of L-pyroglutamic acid as an unusual building block. The diketopiperazines were then thiolated electrophilically to the corresponding bis(methylthio)- and epidithiodiketopiperazines. Initial experiments showed a promising activity towards the generation of reactive oxygen species in HeLa cells.