M. Kalantari, M. Islami, Z. Hassani
Feb 24, 2006
Citations
0
Influential Citations
10
Citations
Journal
SSRN Electronic Journal
Abstract
A general and practical route for the synthesis of phosphorus compounds containing trifluoromethyl or trichloromethyl groups by a one-pot condensation triphenylphosphine and dialkyl acetylenedicarboxylate in the presence of an NH-acid such as 2,2,2-trifluoro-1-(1H- pyrrol-2-yl)ethanone or 2,2,2-trichloro-1-(1H-pyrrol-2-yl)ethanone is described. The product obtained from the fluorinated compound undergoes an intramolecular Wittig reaction in boiling THF. This method offers a simple procedure for the preparation of dimethyl 1-(trifluoromethyl)- 3H-pyrrolizine-2, 3-dicarboxylate.