S. Hehir, Liz O'Donovan, M. P. Carty
May 5, 2008
Citations
0
Influential Citations
17
Citations
Journal
Tetrahedron
Abstract
Abstract Upon thermolysis 5,6-dimethyl- N -[(allyl, but-3-enyl, pent-4-enyl and hex-5-enyl-benzimidazol-2-yl)methylene]-( trans )-2,3-diphenylaziridin-1-amines (Eschenmoser hydrazones) form cyclopropane fused onto pyrrolo-, pyrido-, azepino- and azocino[1,2- a ]benzimidazoles in 70, 50, 77 and 11% yield, respectively. The latter reaction also gave carbene insertion products. Dimethyl group substituents were found to significantly reduce the cytotoxicity of benzimidazolequinone towards human skin fibroblast cells.